Handke is a surname. Notable people with the surname include:
Johann Christoph Handke (1694–1774), Moravian baroque painter Georg Ulrich Handke (1894-1962), German politician Peter Handke (born 1942), Austrian writer and playwright Mirosław Handke (1946-2021), Polish chemist and politician Jürgen Handke (born 1954), German linguist Rebecca Handke (born 1986), German pair skater Christopher Handke (born 1989), German footballer
See also Hanke