Dubos is a French surname. Notable people with the surname include:
Jean-Baptiste Dubos (1670–1742), French writer Jean-François Dubos (born 1945), French businessman René Dubos (1901–1982), American scientist
See also Charles Du Bos (1882–1939), French essayist and critic Marie-Jeanne Renard du Bos (1700 – between 1730 and 1750), French engraver Dubois (disambiguation) DuBose (disambiguation)