Gamache is a surname. Notable people with the surname include:
Joey Gamache (born 1966), American boxer Justinne Gamache, American singer Simon Gamache (born 1981), Canadian ice hockey player
Fictional characters Henri Gamache, pseudonym of an otherwise unknown folk magic author of the 1940s Chief Inspector Armand Gamache, the main character in a series of mystery novels written by Canadian author Louise Penny
See also Gamache River (disambiguation)