7-cyano-7-deazaguanine synthase (, preQ0 synthase, 7-cyano-7-carbaguanine synthase, queC (gene)) is an enzyme with systematic name 7-carboxy-7-carbaguanine:ammonia ligase (ADP-forming). This enzyme catalyses the following chemical reaction

7-carboxy-7-carbaguanine + NH3 + ATP 7-cyano-7-carbaguanine + ADP + phosphate + H2O

This enzyme binds Zn2+.

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