(+)-Caryolan-1-ol synthase (, GcoA) is an enzyme with systematic name (+)-β-caryophyllene hydrolase (cyclizing, (+)-caryolan-1-ol-forming). This enzyme catalyses the following chemical reaction
(+)-β-caryophyllene + H2O (+)-caryolan-1-ol
This enzyme also forms (+)-β-caryophyllene from farnesyl diphosphate ().
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