SGDS may refer to:
Association des Scouts et Guides du Senegal, one of Senegal's Scouting and Guiding organizations. Spontaneous Genome Degeneration Syndrome, a fictional and deadly man-made virus, in the Soldiers of Anarchy video game. Succinylglutamate desuccinylase, an enzyme that catalyzes a chemical reaction.
See also SGD (disambiguation)