Nardilysin () is an enzyme that in humans is encoded by the gene NRDC (formally NRD1). Nardilysin is a type of protease, which means it functions to cut the bonds between certain amino acids. More specifically, it’s an endopeptidase that cleaves bonds at the N-terminus of arginine residues connected to other basic amino acids. This activity also explains its alternative name, N-arginine dibasic convertase, hence its standard name.
Interactions Nardilysin has been shown to interact with Heparin-binding EGF-like growth factor.
Enzyme activity
Nardilysin is a type of enzyme also called N-arginine dibasic convertase or NRD-convertase. This enzyme catalyses the following chemical reaction:
Hydrolysis of polypeptides, preferably at -Xaa-Arg-Lys-, and less commonly at -Arg-Arg-Xaa-, in which Xaa is not Arg or Lys
References
Further reading