William Clayton may refer to:
Politics United Kingdom William Clayton (Liverpool MP) (died 1715), Member of Parliament for Liverpool, 1698–1708 Sir William Clayton, 1st Baronet (died 1744), Member of Parliament for Bletchingley, 1715–1744 William Clayton, 1st Baron Sundon (1671–1752), MP for Woodstock, St Albans, Westminster, Plympton Erle and St Mawes William Clayton (died 1783) (c. 1718–1783), MP for Bletchingley, 1745–1761, and Great Marlow, 1761–1783 Sir William Clayton, 4th Baronet (1762–1834), Member of Parliament for Great Marlow, 1783–1790 Sir William Clayton, 5th Baronet (1786–1866), Member of Parliament for Great Marlow, 1832–1842
United States William F. Clayton (1923–2017), US politician William C. Clayton (1831–1915), American educator, lawyer, politician, and businessperson W. H. H. Clayton (1840–1920), American soldier, lawyer, judge in post-Civil War Arkansas and Indian Territory Oklahoma William L. Clayton (1880–1966), US assistant secretary of state for economic affairs William Clayton (colonist) (1632–1689), acting Governor of the Pennsylvania Colony, 1684–1685 William Wirt Clayton (1812–1885), judge, director and tax collector in Atlanta, Georgia William M. Clayton (1824–?), US politician, mayor of Denver, Colorado, 1868–1869
Other William Clayton (Mormon) (1814–1879), Mormon pioneer William Clayton (architect) (1823–1877), prominent New Zealand architect William Clayton (publisher), publisher of Astounding Stories William Cecil Clayton, a character in Edgar Rice Burroughs's Tarzan novels William Clayton (Arrowverse), a character in the TV series Arrow William Clinton Clayton Jr. (1929–1998), American courier driver and murder victim
See also Clayton baronets Clayton (disambiguation) Clayton (name)