Dejanović () is a Serbian surname derived from the male given name Dejan. Notable people with the surname include:
Dejanović noble family, a Serbian noble family prominent in the 14th century Darko Dejanovic (born 1970), American businessman Darko Dejanović (born 1995), Serbian football goalkeeper Peđa Dejanović (born 1982), Bosnian handball goalkeeper Slavica Đukić Dejanović (born 1951), Serbian politician, current Minister of Health in the Government of Serbia