Hoxie is a surname. Notable people with the surname include:
Al Hoxie (1901–1982), American film actor Andrew Hoxie (born 1986), American professional soccer player Charles A. Hoxie (1867–1941), American scientist Herbert Melville Hoxie (1830-1886), American pioneer, abolitionist, railroad executive Jack Hoxie (1885–1965), American rodeo rider and actor Jean Hoxie (1898–1970), American tennis player and coach John Randolph Hoxie (1831–1896), American politician and business person Joseph C. Hoxie (1814-1870), American architect R. Gordon Hoxie (1919–2002), American educator and college administrator Robert F. Hoxie (1868–1916), American economist Richard L. Hoxie (1844–1930), American brigadier general