Mandelson is a surname. Notable persons with this surname include:

Ben Mandelson (born 1953), English world musician Jill Mandelson, a character in 31 North 62 East Kimberly Mandelson, a character in 31 North 62 East Peter Mandelson (born 1953), British politician

See also Mandelson: The Real PM?, a 2010 documentary film about Peter Mandelson Mendelssohn (surname)