Skyles may refer to:
Places Skyles, West Virginia, an unincorporated community, United States Skyles Creek, a stream, West Virginia, United States
People Charles Skyles, an American politician N. H. Skyles, an American football coach Ethel Skyles Alexander (1925-2016), an American politician
Other Skyles Electric Works
See also Scyles, a Scythian king who lived around 500 BC