Futalosine hydrolase (, futalosine nucleosidase, MqnB) is an enzyme with systematic name futalosine ribohydrolase. It catalyses the following chemical reaction:
The enzyme characterised from Streptomyces species hydrolyses futalosine to dehypoxanthine futalosine and hypoxanthine as a step in the biosnthesis of menaquinone in some prokaryotes. The enzyme has been studied as a means of regulating menaquinone production, and as a means of controlling Helicobacter pylori, a cause of peptic ulcer disease.
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