DNA-3-methyladenine glycosylase II

DNA-3-methyladenine glycosylase II () is an enzyme that catalyses the following chemical reaction:

Hydrolysis of alkylated DNA, releasing 3-methyladenine, 3-methylguanine, 7-methylguanine, and 7-methyladenine

Involved in the removal of alkylated bases from DNA in Escherichia coli.

Evolution

Through the process of convergent evolution, there are at least two unrelated protein folds that share the same DNA-3-methyladenine glycosylase activity. The first, the AlkA N-terminal domain, is found in bacteria . The second, methylpurine-DNA glycosylase (MPG) is found in vertebrates including humans.

Nomenclature

DNA-3-methyladenine glycosylase II is also known as deoxyribonucleate 3-methyladenine glycosides II 3-methyladenine DNA glycosylase II DNA-3-methyladenine glycosides II AlkA alkylated-DNA glycohydrolase (releasing methyladenine and methylguanine)

See also MAG1 (DNA-3-methyladenine glycosylase)

References

External links