Mannosylglycerate hydrolase (, 2-O-(6-phospho-mannosyl)-D-glycerate hydrolase, alpha-mannosidase, mngB (gene)) is an enzyme with systematic name 2-O-(6-phospho-alpha-D-mannosyl)-D-glycerate acylhydrolase. It catalyses the following chemical reaction
The enzyme characterised from Escherichia coli removes the mannose glycoside unit from 2-(α-D-mannosyl)-D-glyceric acid, to give α-D-mannose and D-glyceric acid. The reaction in part of the mannosylglycerate degradation pathway in some extremophiles. The crystal structure of the enzyme from Thermus thermophilus has been determined. Evolution of the genes encoding this enzyme in red algae have been studied.
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