Glucan 1,6-α-isomaltosidase (, exo-isomaltohydrolase, isomalto-dextranase, isomaltodextranase, G2-dextranase, 1,6-α-D-glucan isomaltohydrolase) is an enzyme with systematic name 6-α-D-glucan isomaltohydrolase. It catalyses hydrolysis of (1→6)-β-D-glucosidic linkages in polysaccharides, to remove successive isomaltose units from the non-reducing ends of the chains

Optimum activity is on those 1,6-α-D-glucans containing 6, 7 and 8 glucose units.

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