D-glycero-α-D-manno-heptose 1,7-bisphosphate 7-phosphatase (EC 3.1.3.83) is an enzyme with systematic name D-glycero-α-D-manno-heptose 1,7-bisphosphate 7-phosphohydrolase. It catalyses a chemical reaction in which one of the phosphate groups in D-glycero-α-D-manno-heptose 1,7-bisphosphate is removed by hydrolysis, leaving the second phosphate group at the anomeric centre.

The reaction is part of the biosynthesis of GDP-D-glycero-α-D-manno-heptose when the product is acted on by the enzyme D-glycero-α-D-manno-heptose 1-phosphate guanylyltransferase.

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