Ephraim is a surname. Notable people with the surname include:
Alonzo Ephraim (born 1981), American football player Hogan Ephraim (born 1988), English football player Molly Ephraim (born 1986), American actress Moses Ephraim (1620–1688), Dutch banker Olaf Ephraim (born 1965), Dutch banker and politician Veitel Heine Ephraim (1703-1775), Prussian jeweller, mintmaster and entrepreneur