UDP-N-acetylgalactosamine diphosphorylase () is an enzyme with systematic name UTP:N-acetyl-alpha-D-galactosamine-1-phosphate uridylyltransferase. This enzyme catalyses the following reversible chemical reaction
The enzyme characterised from humans and pig liver combines uridine triphosphate and N-acetyl-α-D-galactosamine 1-phosphate (1) to give uridine diphosphate N-acetylgalactosamine (UDP-GalNAc), with pyrophosphate (PPi) as a byproduct.
The enzyme from plants and animals also acts on N-acetyl-alpha-D-glucosamine 1-phosphate.
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