Adenosyl-chloride synthase (, chlorinase, 5'-chloro-5'-deoxyadenosine synthase) is an enzyme with systematic name S-adenosyl-L-methionine:chloride adenosyltransferase. It was characterised from the marine bacterium, Salinispora tropica, and catalyses a chemical reaction that converts S-adenosyl methionine to 5'-chloro-5'-deoxyadenosine and L-methionine using a chloride ion ():
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