Mannosylglucosyl-3-phosphoglycerate synthase (, MggA) is an enzyme with systematic name GDP-mannose:2-O-(alpha-D-glucosyl)-3-phospho-D-glycerate 2-O-alpha-D-mannosyltransferase. It catalyses the following chemical reaction:
A mannose sugar group is transferred from GDP-mannose to one of the hydroxy groups of the glucose unit of the starting material. This gives 2-O-[α-D-mannopyranosyl-(1→2)-α-D-glucopyranosyl]-3-O-phospho-D-glyceric acid (1), with guanosine diphosphate as a byproduct. The enzyme was characterised from the thermophilic bacterium, Petrotoga mobilis, where it forms the penultimate step in the biosynthesis of mannosylglucosylglycerate, a compound which protects the organism from osmotic shock.
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