Alpha,alpha-trehalose synthase (, trehalose synthase, trehalose synthetase, UDP-glucose:glucose 1-glucosyltransferase, TreT, PhGT) is an enzyme with systematic name ADP-glucose:D-glucose 1-alpha-D-glucosyltransferase. This enzyme catalyses the following chemical reaction
This reversible reaction forms trehalose by combining D-glucose with a second glucose unit which is attached to the phosphate group of a nucleoside such as uridine diphosphate (UDP) or adenosine diphosphate. The enzyme first characterised from Thermococcus litoralis requires magnesium ion, Mg2+ for maximal activity. It has also been found in other thermophilic bacteria including Pyrococcus horikoshii, Rubrobacter xylanophilus, and Thermoproteus tenax.
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