Acetoacetyl-CoA synthase (, NphT7) is an enzyme with systematic name acetyl-CoA:malonyl-CoA C-acetyltransferase (decarboxylating). This enzyme catalyses the following chemical reaction
The enzyme from the soil bacterium Streptomyces sp. CL190 produces acetoacetyl-CoA, which is incorporated into the mevalonate pathway.
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