Mangosuthu Buthelezi (1928–2023) was a South African politician and Zulu prince.
Buthelezi or Butelezi may also refer to:
Tribe Buthelezi (tribe), a Zulu-speaking tribe in South Africa, assimilated under Shaka during the Mfecane, the name survives as a surname
People Anna Buthelezi (born 1965), South African politician Sbuyiselwe Angela Buthelezi (1969–2024), South African politician Gideon Buthelezi (born 1986), South African light flyweight boxer Linda Buthelezi (born 1969), South African footballer who played as a midfielder Mbongeni Buthelezi (born 1956), South African artist who "painted" in plastic Melusi Buthelezi (born 1998), South African soccer player Peter Fanyana John Butelezi, South African archbishop, Roman Catholic Archdiocese of Bloemfontein Zuzifa Buthelezi (born 1955), South African politician