Alfano is an Italian surname. Notable people with the surname include:
Angelino Alfano (born 1970), Italian politician Enrico Alfano (1869 or 1870-unknown), Italian mobster Franco Alfano (1875–1954), Italian composer Graciela Alfano (born 1952), Argentine model JoAnn Alfano, American television producer Robert Alfano, American physicist Thomas Alfano (born 1959), American politician Vanessa Alfano (born 1976), American television journalist Vincenzo Alfano (1850 – ), Italian sculptor
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