6-deoxy-5-ketofructose 1-phosphate synthase (, DKFP synthase, MJ1585 (gene)) is an enzyme with systematic name 2-oxopropanal:D-fructose 1,6-bisphosphate glycerone-phosphotransferase. It catalyses two related chemical reactions. Both form 1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate (6-deoxy-5-ketofructose 1-phosphate) from a fructose phosphate starting material. In one reaction, fructose-1,6-diphosphate is combined with methylglyoxal:
Alternatively, fructose 6-phosphate and methylglyoxal give the same main product but with D-glyceraldehyde as byproduct. This enzyme, characterised from Methanocaldococcus jannaschii is part of a pathway for the biosynthesis of 3-dehydroquinate, and hence aromatic amino acids.
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