4-dimethylallyltryptophan N-methyltransferase (, fgaMT (gene), easF (gene)) is an enzyme with systematic name S-adenosyl-L-methionine:4-(3-methylbut-2-enyl)-L-tryptophan N-methyltransferase. It catalyses the following chemical reaction
This is a methylation reaction in which the methyl group comes from the cofactor, S-adenosyl methionine (SAM), which becomes S-adenosyl-L-homocysteine (SAH). The enzyme was characterised from Aspergillus fumigatus. It catalyses a step in the pathway leading to biosynthesis of ergot alkaloids in that fungus.
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