TRNA (guanine6-N2)-methyltransferase (, methyltransferase Trm14, m2G6 methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:tRNA (guanine6-N2)-methyltransferase. This enzyme catalyses the following chemical reaction
S-adenosyl-L-methionine + guanine6 in tRNA S-adenosyl-L-homocysteine + N2-methylguanine6 in tRNA
The enzyme specifically methylates guanine6 at N2 in tRNA.
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