Mycinamicin VI 2''-O-methyltransferase (, MycE) is an enzyme with systematic name S-adenosyl-L-methionine:mycinamicin VI 2''-O-methyltransferase. This enzyme catalyses the following chemical reaction:

S-adenosyl-L-methionine + mycinamicin VI S-adenosyl-L-homocysteine + mycinamicin III

The enzyme is involved in the biosynthesis of mycinamicin macrolide antibiotics.

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