Flavonoid 4'-O-methyltransferase (, SOMT-2, 4'-hydroxyisoflavone methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:flavonoid 4'-O-methyltransferase. This enzyme catalyses the following chemical reaction
This is a methylation reaction in which the flavanone, naringenin, is converted to a specific methyl ether, isosakuranetin (ponciretin). The methyl group comes from the cofactor, S-adenosyl methionine (SAM), which becomes S-adenosyl-L-homocysteine (SAH). The enzyme was characterised from soybean.
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