Nersisyan () is an Armenian surname. Notable people with the surname include:
Anni Nersisyan, Armenian footballer Arsen Nersisyan (born 1987), Armenian alpine skier Gurgen Nersisyan (born 1985), Armenian politician Hrachia Nersisyan (1895–1961), Soviet-Armenian film actor Louisa Nersisyan (born 1977), Armenian actress
See also Nersessian