Medel is a Spanish surname. Notable people with the surname include:
Anthony Medel (born 1978), American beach volleyball player Braulio Medel Cámara (born 1947), Spanish businessman Elena Medel (born 1985), Spanish poet José Medel (1938–2001), Mexican boxer Gary Medel (born 1987), Chilean footballer Lorenzo Medel, Filipino pianist Marco Medel (born 1989), Chilean footballer Pedro Medel (born 1991), Cuban swimmer