Multisite-specific tRNA:(cytosine-C5)-methyltransferase (, multisite-specific tRNA:m5C-methyltransferase, TRM4 (gene)) is an enzyme with systematic name S-adenosyl-L-methionine:tRNA (cytosine-C5)-methyltransferase. This enzyme catalyses the following chemical reaction
(1) S-adenosyl-L-methionine + cytosine34 in tRNA precursor S-adenosyl-L-homocysteine + 5-methylcytosine34 in tRNA precursor (2) S-adenosyl-L-methionine + cytosine40 in tRNA precursor S-adenosyl-L-homocysteine + 5-methylcytosine40 in tRNA precursor (3) S-adenosyl-L-methionine + cytosine48 in tRNA S-adenosyl-L-homocysteine + 5-methylcytosine48 in tRNA (4) S-adenosyl-L-methionine + cytosine49 in tRNA S-adenosyl-L-homocysteine + 5-methylcytosine49 in tRNA
The enzyme from Saccharomyces cerevisiae is responsible for complete 5-methylcytosine methylations of yeast tRNA.
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