Dimethylglycine N-methyltransferase (, BsmB, DMT) is an enzyme with systematic name S-adenosyl-L-methionine:N,N-dimethylglycine N-methyltransferase (betaine-forming). This enzyme catalyses the following chemical reaction
The enzyme adds a methyl group to N.N-dimethylglycine, giving the product betaine, trimethylglycine. The methyl group comes from the cofactor, S-adenosyl methionine (SAM), which becomes S-adenosyl-L-homocysteine (SAH). The enzyme was characterised from the cyanobacterium, Synechococcus sp. WH8102. Unlike the related enzyme, sarcosine/dimethylglycine N-methyltransferase, sarcosine is not a substrate.
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