Smithwick is a surname. Notable people with the surname include:
Emma Smithwick, English TV producer Frederick Smithwick (1879–1962), Irish rugby international Gladys Smithwick (1898–1964), American medical missionary Hugh Smithwick (1918–1990), American football player and coach Jan Smithwick (born 1952), Australian basketball player John Francis Smithwick (1844–1913) Irish businessman and politician John H. Smithwick (1872–1948), American politician Noah Smithwick (1808–1899), Texas colonist Peter Smithwick (1937–2022), Irish judge