Germacrene A hydroxylase () is an enzyme with systematic name (+)-germacrene-A,NADPH:oxygen oxidoreductase (12-hydroxylating). It catalyses a sequence of three oxidation reactions. The first converts (+)-germacrene A to an alcohol by addition of a hydroxy group:
Germacrene A hydroxylase is a cytochrome P450 protein containing heme. It requires a partner cytochrome P450 reductase for functional expression. This uses nicotinamide adenine dinucleotide phosphate. After two further oxidation steps, the product is germacrene A acid.
The product is further converted in chicory plants to a sesquiterpene lactone.
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