The 1965–66 Macedonian Republic League was the 23rd since its establishment. Rabotnichki Skopje won their 6th championship title.
Participating teams Club City Belasica Strumica Borec Titov Veles Bregalnica Shtip Karaorman Struga Ljuboten Tetovo Mavrovo Gostivar MIK Skopje Skopje Napredok Kichevo Pelagonija Bitola Rabotnichki Skopje Rabotnik Bitola Teteks Tetovo Tikvesh Kavadarci Vardar Negotino
Final table
External links SportSport.ba Football Federation of Macedonia