Cuenca is a surname. Notable people with the surname include:
César Cuenca (born 1981), Argentine boxer Christina Cuenca (born 1980), American beauty queen Flor Cuenca (born 1977), Peruvian mountaineer Isaac Cuenca (born 1991), Spanish footballer Jake Cuenca (born 1987), American-born Filipino actor Jean-José Cuenca (born 1986), French footballer João Paulo Cuenca (born 1978), Brazilian writer Jorge Cuenca (born 1999), Spanish footballer Luis Cuenca (1921–2004), Spanish actor María Guadalupe Cuenca (1790–1854), Bolivian-born Argentine letter writer Mario Cuenca (born 1975), Argentine footballer Rodolfo Cuenca (1928–2023), Filipino businessman Victoria Cuenca, 20th-century Argentine actress, vedette Mike Cuenca, an American film director