Carotenoid isomerooxygenase (, ninaB (gene)) is an enzyme with systematic name zeaxanthin:oxygen 15,15'-oxidoreductase (bond-cleaving, cis-isomerizing).
This enzyme catalyses the following chemical reaction:
zeaxanthin + O2 (3R)-11-cis-3-hydroxyretinal + (3R)-all-trans-3-hydroxyretinal
The enzyme from the moth Galleria mellonella and the fruit fly Drosophila melanogaster takes part in the synthesis of retinal.
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