Littleton is both a surname and a masculine given name. Notable people with the name include:

Surname: Littleton baronets, numerous English jurists and politicians Ananias Charles Littleton (1886–1974), American accounting scholar Benjamin Horsley Littleton (1889–1966), American judge C. Scott Littleton (1933–2010), American anthropologist and academic Carol Littleton (born 1942), American film editor Col. Littleton (born 1943), American fashion designer Edward Littleton, 1st Baron Hatherton (1791–1863), British politician Edward Littleton, 2nd Baron Hatherton (1815–1888), British politician Edward Littleton (colonial administrator) (died 1705), English businessman Graceson Littleton (born 2006), American football player Harvey Littleton (1922–2013), American educator and glass artist Herbert A. Littleton (1930–1951), United States Marine Humphrey Littleton (died 1606), English Gunpowder Plotter Jody Littleton (born 1974), American football player Larry Littleton (born 1954), American baseball player Martin W. Littleton (1872–1934), American politician Michael Flannan Littleton (1938–2002), Irish chess master Peggy Littleton, American politician Timothy Littleton (died 1679), English judge Wes Littleton (born 1982), American baseball player

Fictional characters: Claire Littleton, character in the television series Lost

Given name: Littleton Dennis Jr. (1765–1833), associate justice of the Maryland Court of Appeals Littleton Purnell Dennis (1786–1834), American politician Littleton Fowler, American baseball player Littleton Groom (1867–1936), Australian politician Littleton Kirkpatrick (1797–1859), American politician Littleton W. Moore (1835–1911), American politician Littleton Powys (died 1732), English judge Littleton Waller (1856–1926), United States Marine Corps general Littleton Waller Tazewell (1774–1860), American politician Littleton Waller Tazewell Bradford (1848–1918), American politician