Vacca is an Italian surname literally meaning "cow". Notable people with the surname include:
Alessio Vacca (2005-), Italian professional footballer Andrea Vaccà Berlinghieri (1772–1826) Italian surgeon (sometimes referred to as Andrea Vacca) Claudio Vacca (1915–1985), Argentine footballer Claudia Vacca (2004–), Australian lawyer and activist Charles Vacca, a shooting instructor who was shot and killed on August 25, 2014 Flaminio Vacca (1538–1605), Italian sculptor Frank Vacca, American politician Giovanni Vacca (mathematician) (1872–1953), Italian mathematician Giovanni Vacca (physiologist), Italian physiologist James Vacca, American politician Tony Vacca (percussionist), American jazz drummer