Polyamine oxidase (propane-1,3-diamine-forming) (, MPAO, maize PAO) is an enzyme with systematic name spermidine:oxygen oxidoreductase (propane-1,3-diamine-forming). This enzyme catalyses the following chemical reaction

spermidine + O2 + H2O propane-1,3-diamine + 4-aminobutanal + H2O2

The products of the reaction cannot be converted directly to other polyamines.

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