8-Hydroxy-5-deazaflavin:NADPH oxidoreductase (, 8-OH-5dFl:NADPH oxidoreductase) is an enzyme with systematic name reduced coenzyme F420:NADP+ oxidoreductase. This enzyme catalyses the following chemical reaction
reduced coenzyme F420 + NADP+ coenzyme F420 + NADPH + H+
The enzyme requires the 5-deazaflavin structure, as well as an 8-hydroxy group in the substrate.
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