Charles Clay may refer to:
Charles Clay (American football) (born 1989), American football fullback and tight end Charles Clay (patriot) (1745–1820), minister, American planter, clergyman and politician in Virginia Charles Clay (surgeon) (1801–1893), English surgeon Sir Charles Travis Clay (1885–1978), English antiquary and librarian Chuck Clay (Charles Commander Clay, born 1950), American politician, state legislator from Georgia