Serie B is the second level Italian football league.

Serie B may also refer to:

Campeonato Brasileiro Série B, a Brazilian football league Ecuadorian Serie B, an Ecuadorian football league Serie B (baseball), an Italian baseball league Serie B (men's water polo), an Italian water polo league Serie B (women's football), an Italian women's football league Serie B Basket, an Italian basketball league Serie B de México, an association football league Lega B, the governing body of the Serie B Italian football league