Acrylyl-CoA reductase (NADPH) () is an enzyme with systematic name propanoyl-CoA:NADP+ oxidoreductase. This enzyme catalyses the following chemical reaction

propanoyl-CoA + NADP+ acryloyl-CoA + NADPH + H+

This enzyme catalyses a step in the 3-hydroxypropionate/4-hydroxybutyrate cycle, an autotrophic CO2 fixation pathway found in some Thermoacidophilic archaea.

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