Paromamine 6'-oxidase (, btrQ (gene), neoG (gene), kanI (gene), tacB (gene)) is an enzyme with systematic name paromamine:oxygen 6'-oxidoreductase. It catalyses the following chemical reaction
The enzyme characterised from Streptomyces fradiae uses molecular oxygen to convert the primary alcohol of the glucosamine sugar unit into its aldehyde, giving hydrogen peroxide as a byproduct. This is a step in the biosynthesis of several aminoglycoside antibiotics, including kanamycin, butirosin, neomycin and ribostamycin.
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