8-Hydroxygeraniol dehydrogenase

8-hydroxygeraniol dehydrogenase (, 8-hydroxygeraniol oxidoreductase, CYP76B10, G10H, CrG10H, SmG10H, acyclic monoterpene primary alcohol:NADP+ oxidoreductase) is an enzyme with systematic name (6E)-8-hydroxygeraniol:NADP+ oxidoreductase. This enzyme catalyses the following chemical reaction

(6E)-8-hydroxygeraniol + 2 NADP+ (6E)-8-oxogeranial + 2 NADPH + 2 H+ (overall reaction)

(1a) (6E)-8-hydroxygeraniol + NADP+ (6E)-8-hydroxygeranial + NADPH + H+ (1b) (6E)-8-hydroxygeraniol + NADP+ (6E)-8-oxogeraniol + NADPH + H+ (1c) (6E)-8-hydroxygeranial + NADP+ (6E)-8-oxogeranial + NADPH + H+ (1d) (6E)-8-oxogeraniol + NADP+ (6E)-8-oxogeranial + NADPH + H+

This enzyme contains Zn2+. It catalyses the oxidation of (6E)-8-hydroxygeraniol to (6E)-8-oxogeranial via either (6E)-8-hydroxygeranial or (6E)-8-oxogeraniol.

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