Ustyugov () is a Russian masculine surname, its feminine counterpart is Ustyugova. Notable people with the surname include:
Aleksandr Ustyugov (born 1976), Russian actor, film director and musician Evgeny Ustyugov (born 1985), Russian biathlete Gennady Ustyugov (1937–2025), Russian painter Sergey Ustiugov (born 1992), Russian cross-country skier