Upshur may refer to:
Places Upshur County, Texas, county located in the U.S. state of Texas Upshur County, West Virginia, county located in the U.S. state of West Virginia
People Surname Abel P. Upshur (1790–1844), American lawyer, Secretary of the Navy and Secretary of State Franklin Upshur (1875–1965), American politician and lawyer George M. Upshur (1847–1924), American politician and lawyer George P. Upshur (1799–1852), officer in the United States Navy, brother of Abel P. Upshur John Henry Upshur (1823–1917), admiral in the United States Navy in the Mexican-American War and American Civil War Ross Upshur, FRCPC, Canadian physician and researcher William P. Upshur (1881–1943), recipient of the Medal of Honor—for actions in 1915 during the Haitian Campaign William A. Upshur (1894 – 1963), member of the Pennsylvania House of Representatives (1947-1948)
Given name John Upshur Dennis Page (1904–1950), United States Army officer from Saint Paul, Minnesota Robert "Bob" Upshur Woodward (born 1943), American investigative journalist and non-fiction author
Fictional Miles Upshur, protagonist of the 2013 survival horror video game Outlast
Ships USS Abel P. Upshur (DD-193), Clemson class destroyer in the United States Navy USS Upshur (DD-144), Wickes class destroyer in the United States Navy USNS Upshur (T-AP-198), Barrett class transport ship of the United States Navy